Scars Run Deep: Epigenetics and Trauma
- mxrowan7
- Mar 15
- 6 min read

There has been a lot of discussion recently about Breaking the Cycle – taking a stand against cycles of abuse, trauma, bullying, etc. Much of it focuses on making active efforts to recognize when things are unhealthy and choosing to change. What a lot of it lacks, especially in short-form media like tweets, is nuance.
A lot of people who experience extreme trauma or abuse are physically changed – in ways that gets passed down to their children.
Epigenetics is the study of how environmental factors can change how your body processes DNA. It encompasses everything from cancer risk to transgenerational trauma. Basically, environmental factors can change what genes get read, and which don’t, effectively turning them “on” or “off”.

But that means your body physically warps to seeing things differently, processing information differently. And that can be passed on. A surprising amount of children of trauma survivors have horrible nightmares and other symptoms of PTSD, even when given a good upbringing and not told of the trauma. There’s not nearly enough studies on it, but people who experienced that seem to find each other more and more online.
So if you’re predisposed to heightened reactions, adverse reactions, and PTSD like symptoms, you might not even know it. More studies are needed, but based on the Fight, Flight, Freeze, Fawn reactions that exist? Hypothetically, it could explain both bullies that come from otherwise healthy households and the cycle that victims often find themselves in.

But there’s hope!
More and more research is coming out about potential epigenetic treatments. Most of them focus on more physical effects, like predispositions to allergies, cancer, and the like. But imagine a world where both therapy and epigenetic treatment was given to survivors of trauma and their children. Being able to treat trauma and its long term effects on a protein level could revolutionize how we handle trauma and intergenerational symptoms!
And imagine this from the perspective of someone with trauma, or a child of a survivor. Imagine a world where people don’t have to fight against or argue with their own intrusive thoughts or memories, don’t have to spend far more energy on emotional regulation than their peers, and aren’t stuck with lifelong nightmares that may never receive treatment.
As of yet, there’s no formal organizations created to fund or study this phenomenon. The research currently coming out is from major universities – from Johns Hopkins to MIT and more.
Someday we may just live in that world. But more social awareness is needed, more research is needed, and more global awareness is needed. Self-awareness is especially important, even and especially for those who don’t think are affected by any of this. The thing about protein reactions is that you can’t see them. Without lots of tests, it’s not possible to know if a quick temper, a closed mind, a rejection sensitivity, or irrational fear is coming from experience or biochemistry.
In the meantime, there’s lots of emotional regulation coping skills and exercises. Therapy is for everyone, even those who don’t think they need it.
And as always, be kind to each other. You never know what someone – even yourself – may be dealing with.
Works Cited:
“A Review of Epigenetic Contributions to Post-Traumatic Stress Disorder.” Dialogues in Clinical Neuroscience, 2019, www.tandfonline.com/doi/full/10.31887/DCNS.2019.21.4/kressler, https://doi.org/10.31887//DCNS.2019.21.4//kressler. Accessed 30 Dec. 2023.
“A Three-Generational Study of Transmission of Risk for Sexual Abuse.” Journal of Clinical Child and Adolescent Psychology, 2023, www.tandfonline.com/doi/abs/10.1207/s15374424jccp3304_2. Accessed 30 Dec. 2023.
“APA PsycNet.” Apa.org, 2023, psycnet.apa.org/record/2018-00130-004. Accessed 30 Dec. 2023.
“APA PsycNet.” Apa.org, 2023, psycnet.apa.org/record/2016-02082-001. Accessed 30 Dec. 2023.
Blum, Kenneth, et al. “Epigenetic Repair of Terrifying Lucid Dreams by Enhanced Brain Reward Functional Connectivity and Induction of Dopaminergic Homeo - Static Signaling.” Current Psychopharmacology, vol. 10, no. 3, 14 Dec. 2021, pp. 170–180, www.ncbi.nlm.nih.gov/pmc/articles/PMC8547281/, https://doi.org/10.2174/2211556010666210215153513. Accessed 30 Dec. 2023.
CDC. “What Is Epigenetics?” Centers for Disease Control and Prevention, 15 Aug. 2022, www.cdc.gov/genomics/disease/epigenetics.htm#:~:text=Epigenetics%20is%20the%20study%20of,body%20reads%20a%20DNA%20sequence. Accessed 30 Dec. 2023.
Clarivate. “Epigenetics Research, the Top 20 Institutions - ScienceWatch.com.” Sciencewatch.com, 2020, archive.sciencewatch.com/inter/ins/09/09marEpigentop20/. Accessed 30 Dec. 2023.
“Crossing Borders: A Systematic Review Identifying Potential Mechanisms of Intergenerational Trauma Transmission in Asylum-Seeking and Refugee Families.” European Journal of Psychotraumatology, 2020, www.tandfonline.com/doi/full/10.1080/20008198.2020.1790283, https://doi.org/10.1080//20008198.2020.1790283. Accessed 30 Dec. 2023.
Daskalakis, Nikolaos P, et al. “Recent Genetics and Epigenetics Approaches to PTSD.” Current Psychiatry Reports, vol. 20, no. 5, 5 Apr. 2018, link.springer.com/article/10.1007/s11920-018-0898-7, https://doi.org/10.1007/s11920-018-0898-7. Accessed 30 Dec. 2023.
“EBSCOhost | 152018886 | Potentializing Wellness to Overcome Generational Trauma.” Ebscohost.com, 2021, web.s.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=15561542&AN=152018886&h=DDXODfZ481clJFamcZhGbj1xhZaFKF7kZulqfyv0tU1Vx7HatxGQ84UXmho7VKsheVVgbGgrkgGWhwGWt8E35g%3d%3d&crl=c&resultNs=AdminWebAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d15561542%26AN%3d152018886. Accessed 30 Dec. 2023.
EPIGENETIC TRANSMISSION Epigenetic Transmission of Holocaust Trauma: Can Nightmares Be Inherited? 2011.
“Fear and Anxiety Drive Conservatives’ Political Attitudes.” Psychology Today, 2016, www.psychologytoday.com/us/blog/mind-in-the-machine/201612/fear-and-anxiety-drive-conservatives-political-attitudes. Accessed 30 Dec. 2023.
Fischmann, Tamara. “Dreams, Unconscious Fantasies and Epigenetics.” Springer EBooks, 1 Jan. 2016, pp. 91–105, link.springer.com/chapter/10.1007/978-3-319-17605-5_6, https://doi.org/10.1007/978-3-319-17605-5_6. Accessed 30 Dec. 2023.
Gal Warhaftig, et al. “Deconvoluting the Functional Role of DNA Methylation in Trauma; Implications for Epigenetic Therapy and Prospects of Targeted “Epigenetic Therapy.”” Elsevier EBooks, 1 Jan. 2023, pp. 81–92, www.sciencedirect.com/science/article/abs/pii/B9780128239377000092, https://doi.org/10.1016/b978-0-12-823937-7.00009-2. Accessed 30 Dec. 2023.
---. “Reduction of DNMT3a and RORA in the Nucleus Accumbens Plays a Causal Role in Post-Traumatic Stress Disorder-like Behavior: Reversal by Combinatorial Epigenetic Therapy.” Molecular Psychiatry, vol. 26, no. 12, 12 July 2021, pp. 7481–7497, www.nature.com/articles/s41380-021-01178-y, https://doi.org/10.1038/s41380-021-01178-y. Accessed 30 Dec. 2023.
“Generational Trauma, Attachment, and Spiritual/Religious Interventions.” Journal of Loss and Trauma, 2023, www.tandfonline.com/doi/abs/10.1080/15325020903373078. Accessed 30 Dec. 2023.
Grand, Sue, and Jill Salberg. “Trans-Generational Transmission of Trauma.” Springer EBooks, 24 Nov. 2020, pp. 209–215, link.springer.com/chapter/10.1007/978-3-030-47817-9_22, https://doi.org/10.1007/978-3-030-47817-9_22. Accessed 30 Dec. 2023.
Jacobs, Janet. “The Cross-Generational Transmission of Trauma: Ritual and Emotion among Survivors of the Holocaust - Janet Jacobs, 2011.” Journal of Contemporary Ethnography, 2016, journals.sagepub.com/doi/abs/10.1177/0891241610387279. Accessed 30 Dec. 2023.
Jiang, Shui, et al. “Epigenetic Modifications in Stress Response Genes Associated with Childhood Trauma.” Frontiers in Psychiatry, vol. 10, 8 Nov. 2019, www.frontiersin.org/articles/10.3389/fpsyt.2019.00808/full, https://doi.org/10.3389/fpsyt.2019.00808. Accessed 30 Dec. 2023.
Krippner, Stanley, and Deirdre Barrett. “Transgenerational Trauma: The Role of Epigenetics.” The Journal of Mind and Behavior, vol. 40, no. 1, 2019, pp. 53–62, www.jstor.org/stable/26740747.
Lehrner, Amy, and Rachel Yehuda. “Cultural Trauma and Epigenetic Inheritance.” Development and Psychopathology, vol. 30, no. 5, 28 Sept. 2018, pp. 1763–1777, www.cambridge.org/core/journals/development-and-psychopathology/article/abs/cultural-trauma-and-epigenetic-inheritance/8C1FC1DCFF459B4B07F574386627F9DD, https://doi.org/10.1017/s0954579418001153. Accessed 30 Dec. 2023.
Lev–Wiesel, Rachel. “Intergenerational Transmission of Trauma across Three Generations: A Preliminary Study - Rachel Lev–Wiesel, 2007.” Qualitative Social Work, 2016, journals.sagepub.com/doi/abs/10.1177/1473325007074167. Accessed 30 Dec. 2023.
“Lost in Transmission: Studies of Trauma across Generations.” The International Journal of Psychoanalysis, 2014, www.tandfonline.com/doi/full/10.1111/1745-8315.12092. Accessed 30 Dec. 2023.
Mihaela Minulescu. “Approaching Trans-Generational Trauma in Analytical Psychotherapy.” Procedia - Social and Behavioral Sciences, vol. 217, 1 Feb. 2016, pp. 1112–1117, www.sciencedirect.com/science/article/pii/S187704281600149X, https://doi.org/10.1016/j.sbspro.2016.02.124. Accessed 30 Dec. 2023.
“Nightmares and Stress: A Longitudinal Study | Journal of Clinical Sleep Medicine.” Journal of Clinical Sleep Medicine, 2019, jcsm.aasm.org/doi/full/10.5664/jcsm.7904. Accessed 30 Dec. 2023.
Pears, Katherine C, and Deborah M Capaldi. “Intergenerational Transmission of Abuse: A Two-Generational Prospective Study of an At-Risk Sample.” Child Abuse & Neglect, vol. 25, no. 11, 1 Nov. 2001, pp. 1439–1461, www.sciencedirect.com/science/article/abs/pii/S0145213401002861, https://doi.org/10.1016/s0145-2134(01)00286-1. Accessed 30 Dec. 2023.
Pedersen, Walker S, et al. “Conservatism and the Neural Circuitry of Threat: Economic Conservatism Predicts Greater Amygdala–BNST Connectivity during Periods of Threat vs Safety.” Social Cognitive and Affective Neuroscience, vol. 13, no. 1, 6 Nov. 2017, pp. 43–51, www.ncbi.nlm.nih.gov/pmc/articles/PMC5793824/#:~:text=Political%20conservatism%20is%20associated%20with,toward%20negative%20and%20threatening%20stimuli., https://doi.org/10.1093/scan/nsx133. Accessed 30 Dec. 2023.
Pfeiffer, John R, et al. “Traumatic Stress Epigenetics.” Current Behavioral Neuroscience Reports, vol. 5, no. 1, 13 Feb. 2018, pp. 81–93, link.springer.com/article/10.1007/s40473-018-0143-z, https://doi.org/10.1007/s40473-018-0143-z. Accessed 30 Dec. 2023.
Scharf, Miri. “Long-Term Effects of Trauma: Psychosocial Functioning of the Second and Third Generation of Holocaust Survivors.” Development and Psychopathology, vol. 19, no. 02, 1 Apr. 2007, www.cambridge.org/core/journals/development-and-psychopathology/article/abs/longterm-effects-of-trauma-psychosocial-functioning-of-the-second-and-third-generation-of-holocaust-survivors/71D58A994861C3CA284CA86AD7D74F7A, https://doi.org/10.1017/s0954579407070290. Accessed 30 Dec. 2023.
Stroh, Perlita. “How Trauma Suffered by Holocaust Survivors Has Affected the next Generation.” CBC, 27 Jan. 2023, www.cbc.ca/news/canada/holocaust-survivors-children-psychological-impact-trauma-1.6489378. Accessed 30 Dec. 2023.
“Study Links Epigenetic Changes to Historic Trauma in Alaska Native Communities | Carl R. Woese Institute for Genomic Biology.” Illinois.edu, 2023, www.igb.illinois.edu/article/study-links-epigenetic-changes-historic-trauma-alaska-native-communities. Accessed 30 Dec. 2023.
Thomas, Hannah J, et al. “Why Do Children and Adolescents Bully Their Peers? A Critical Review of Key Theoretical Frameworks.” Social Psychiatry and Psychiatric Epidemiology, vol. 53, no. 5, 22 Nov. 2017, pp. 437–451, link.springer.com/article/10.1007/s00127-017-1462-1, https://doi.org/10.1007/s00127-017-1462-1. Accessed 30 Dec. 2023.
Thumfart, Kristina, et al. “Epigenetics of Childhood Trauma: Long Term Sequelae and Potential for Treatment.” Neuroscience & Biobehavioral Reviews, vol. 132, 1 Jan. 2022, pp. 1049–1066, www.sciencedirect.com/science/article/pii/S014976342100484X, https://doi.org/10.1016/j.neubiorev.2021.10.042. Accessed 30 Dec. 2023.
“Trauma- and Stressor-Related Disorders.” Google Books, 2018, books.google.com/books?hl=en&lr=&id=cIJZDwAAQBAJ&oi=fnd&pg=PA161&dq=epigenetics+and+nightmares&ots=bi11mMtJ82&sig=z71WkmN-y_iYzzKE7MScpQprsL4#v=onepage&q=epigenetics%20and%20nightmares&f=false. Accessed 30 Dec. 2023.
“Wounds of History.” Google Books, 2016, books.google.com/books?hl=en&lr=&id=vi8lDwAAQBAJ&oi=fnd&pg=PP1&dq=generational+trauma+study&ots=tIJTLpqlHL&sig=B1CxSsaW7Vyx9gwweeWt-cdVBZk#v=onepage&q=generational%20trauma%20study&f=false. Accessed 30 Dec. 2023.
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